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KMID : 0388120020110040356
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Journal of Korean Society for the Study of Obesity
2002 Volume.11 No. 4 p.356 ~ p.361
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Circulating Ghrelin Levels and Fat Distribution in Obese Patients
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Suh Young-Sung
Kim Dae-Hyun
Lee In-Kyu
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Abstract
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Background : Ghrelin, a novel GH-releasing peptide isolated from human and rat stomach, stimulates food intake and GH secretion. We investigated the relationships between plasma ghrelin concentrations and fat distributions in obese patients.
Methods : The subjects included 57 nonobese subjects and 123 subjects with obesity. Waist and hip circumference were measured by standard method. Abdominal CT was used to measure abdominal adipose tissue at the level of lumbar vertebrae 4 ~ 5. Fasting blood samples for ghrelin were collected from all subjects.
Results : Circulating ghrelin levels in nonobese subjects were significantly higher (615.0±341.3 pg/mL) than in obese subjects (517.1 kg/㎡ 141.4 pg/mL) (p=0.007). In obese subjects, there were significantly more visceral fat amounts of patient with < 500 pg/mL of ghrelin levels than that’s of patient with ≥ 500 pg/mL of ghrelin levels (P=0.023). But, in stepwise regression analysis, BMI was a significant independent determinant of fasting ghrelin in obese patients (R^2 0.06, P=0.006) and hip circumference was a major determinants of fasting ghrelin levels in total subjects (R^2 0.066, p=0.001).
Conclusions : In this study, we found that circulating ghrelin levels in obese subjects are lower than nonobese subjects. The major determinant of ghrelin levels in obese subjects are BMI rather than visceral fat amount.
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KEYWORD
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Ghrelin, Obesity, Abdominal visceral fat, BMI
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